Procoagulant Activity of Platelets and Tissue Factor Microparticles in Behçets Disease
نویسندگان
چکیده
منابع مشابه
Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity.
In the present study we investigated whether endothelial microparticles (EMPs) can bind to monocytic THP-1 cells and modulate their procoagulant properties. Using flow cytometry, we demonstrated that EMPs express adhesive receptors similar to those expressed by activated endothelial cells. Expression of endothelial antigens by THP-1 cells incubated with EMP was shown by immunoperoxidase stainin...
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Coagulation factor Xa appears involved in the pathogenesis of pulmonary fibrosis. Through its interaction with protease activated receptor-1, this protease signals myofibroblast differentiation in lung fibroblasts. Although fibrogenic stimuli induce factor X synthesis by alveolar cells, the mechanisms of local posttranslational factor X activation are not fully understood. Cell-derived micropar...
متن کاملProcoagulant Activity of Adherent Platelets
........................................................................................................................ 9 INTRODUCTION ............................................................................................................... 11 REVIEW OF THE LITERATURE ...................................................................................... 13 1. Platelets .....................
متن کاملProcoagulant Activity of Adherent Platelets
The possibility that platelets release microvesicles on adherence to either von Willebrand factor (vWf) or collagen was examined by flow cytometry analysis of the supernatant above layers of adherent platelets. No microvesicle release was detected as a result of adherence to vWf or to collagen, a known platelet agonist. Approximately 8% of the total platelet mass was released as microvesicles a...
متن کاملPhosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients.
BACKGROUND Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activity in colon cancer patients. METHODS PS-positive platelets and MPs, mainly...
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ژورنال
عنوان ژورنال: The Egyptian Journal of Hospital Medicine
سال: 2019
ISSN: 2090-7125
DOI: 10.21608/ejhm.2019.27632